Thrombopoietin

It stimulates the production and differentiation of . Eur J Gastroenterol Hepatol. Thrombopoietin (TPO) is the physiologically relevant regulator of platelet production. Author information: (1)Institute of Physiology, Medical University of Lubeck, Lubeck, Germany. The liver plays an important role in the .

Rios R(1), Sangro B, Herrero I, Quiroga J, Prieto J. The role of thrombopoietin in the thrombocytopenia of patients with liver cirrhosis. OBJECTIVES: Thrombocytopenia is a common disorder . Studies using recombinant thrombopoetin have led to the development of antithrombopoietin antibodies in normal subjects which raises the issue of safety of its use in . This molecule is indeed the long-sought-after hematopoietic factor that controls platelet production. TPO is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis.

The hormone is in most cases written as THPO.

Find MSDS or SDS, a COA, data sheets and more information. The Quantikine Human Tpo Immunoassay is a 4. ELISA designed to measure human Tpo in cell culture supernates, serum, and plasma. It contains recombinant human Tpo and antibodies raised against the recombinant factor. Defects in the Tpo‑Tpo R signaling pathway are associated with a variety of platelet disorders (1‑3).

The 3amino acid (aa) human Tpo . This test will be used to measure serum TPO level in patients with thrombocytopenia of unknown cause. ITP (Idiopathic Thrombocytopenia purpura) is a common cause of thrombocytopenia. In addition to its actions on thrombopoiesis, TPO directly modulates the homeostatic potential of mature platelets by influencing their response to . Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells.

It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. GeneCards - The Human Gene Compendium. Patient Preparation: Collect: Plain Red.

Separate specimens must be submitted when multiple tests are ordered. Find product specific information including CAS, MSDS, protocols and references.

Referenced in publication.